Anti-CHAC1 Antibody

CHAC1 (ChaC Glutathione Specific Gamma-Glutamylcyclotransferase 1) is a gamma-glutamylcyclotransferase enzyme that cleaves the gamma-glutamyl bond of glutathione and has been linked to the unfolded protein response (UPR), endoplasmic reticulum stress signaling, and ferroptosis regulation. This unconjugated Rabbit polyclonal antibody from Antibodies.com is raised against the CHAC1 protein and provides a specific reagent for researchers tracking glutathione catabolism, oxidative stress pathways, and regulated cell-death mechanisms.

Supplied as 100 µl at 1 mg/ml in phosphate buffered saline (PBS) with 0.05% sodium azide (approx. pH 7.2), the antibody is validated for Western Blot (WB) applications on Human, Mouse, and Rat samples. The polyclonal format delivers broader epitope coverage than a monoclonal reagent, which is useful when probing CHAC1 across multiple species or detecting modest expression changes in stress-response experiments.

Typical WB workflows include examining CHAC1 induction under ER-stress conditions (such as thapsigargin or tunicamycin treatment), tracking glutathione depletion in disease models, and exploring ferroptosis-related mechanisms in cancer and neurodegeneration research. The vial should be handled and stored refrigerated to preserve antibody activity, with sodium azide acting as the included preservative.