Anti-CGB Antibody

This rabbit polyclonal IgG reagent from Antibodies.com is an unconjugated primary antibody that recognizes the beta subunit of human chorionic gonadotropin (CGB), the glycoprotein hormone routinely measured as the pregnancy marker hCG. Supplied as a 200 µL liquid aliquot in a single-use vial, the antibody is validated for Western blot and immunohistochemistry on human samples, supporting work in reproductive biology, placental research, and tumor pathology. CGB expression is retained by syncytiotrophoblast and cytotrophoblast lineages and is re-expressed in gestational trophoblastic disease and several germ cell tumors, including choriocarcinoma and seminoma, which makes this antibody a useful marker in diagnostic IHC of testicular and placental specimens. The CGB genes reside in a tightly linked cluster on chromosome 19q13.3, where six paralogous loci (CGB, CGB1, CGB2, CGB5, CGB7, CGB8) encode closely related beta subunits sharing extensive sequence identity; researchers using non-human samples should consider this homology when interpreting cross-reactivity. For Western blot, the reagent is applied to lysates from placental tissue or choriocarcinoma-derived cell lines, while IHC is performed on formalin-fixed paraffin-embedded tissue sections. The antibody should be stored refrigerated in the supplied vial, with aliquots prepared to limit freeze-thaw cycles and preserve long-term activity for in vitro research use.