Anti-CFI Antibody

A rabbit polyclonal antibody from Antibodies.com that specifically detects human complement factor I (CFI), a key serine protease responsible for regulating the complement cascade through proteolytic cleavage of C3b and C4b. Supplied as 100 µl of unconjugated reagent, this antibody is validated for two complementary workflows: Western blot (WB) for protein-level analysis of CFI expression in cell lysates, and immunofluorescence (IF) for visualizing CFI localization in fixed cells and tissue sections. The polyclonal nature of the reagent means multiple epitopes on the CFI protein are recognized, which is advantageous for detecting denatured targets on membranes and native targets in situ. Researchers investigating complement-mediated pathology, including atypical hemolytic uremic syndrome, C3 glomerulopathy, and age-related macular degeneration, use this reagent to characterize CFI expression patterns in patient-derived samples and relevant disease models. The unconjugated format allows flexible pairing with secondary antibodies labeled with HRP, fluorophores, or biotin, depending on the detection method chosen.