Anti-CENPA Antibody

This rabbit polyclonal antibody from Antibodies.com targets CENPA (Centromere Protein A), a histone H3 variant that replaces conventional H3 within centromeric nucleosomes and serves as the epigenetic foundation for kinetochore assembly during mitosis.

The unconjugated reagent is supplied at 1 mg/ml in Phosphate buffered saline (PBS) containing 0.05% sodium azide at approximately pH 7.3, validated for Western blot detection of the target in human, mouse, and rat samples. Each vial contains 100 µl of working stock; aliquot upon receipt and store at -20°C, protecting the antibody from light and avoiding repeated freeze-thaw cycles to preserve binding activity.

Investigators use this reagent to track chromosome segregation, centromere identity, kinetochore structure, cell cycle progression, and the genomic instability that emerges when CENPA expression becomes dysregulated in tumor cells. The polyclonal format broadens epitope coverage across three mammalian species, supporting comparative cell biology, cancer research, and chromatin immunoprecipitation follow-up workflows.