Anti-CELSR3 Antibody

Raised against CELSR3, an atypical cadherin of the flamingo subfamily that participates in planar cell polarity signaling and neural tube development, this rabbit polyclonal Primary Antibody from Antibodies.com is supplied as a 100 µl aliquot at 1 mg/ml in phosphate buffered saline containing 15 mM sodium azide at approximately pH 7.2. The unconjugated reagent is validated for Western blot on Human, Mouse, and Rat samples, supporting comparative expression studies in neuroscience, developmental biology, and epithelial polarity research. Because CELSR3 is a large multi-domain receptor with extracellular cadherin repeats, a seven-pass transmembrane region, and a long cytoplasmic tail, the polyclonal format captures several independent epitopes and tolerates minor sequence variation between orthologs more readily than a monoclonal reagent. For Western blot lysate preparation, the antibody performs well with standard RIPA-extracted brain, neural crest, or embryonic tissue homogenates, and aliquoting prior to long-term storage preserves activity across repeated freeze-thaw cycles. Refrigerate for routine bench use and observe standard sodium azide handling precautions.