Anti-CEACAM1 / 5 Antibody

This rabbit polyclonal reagent from Antibodies.com recognizes human CEACAM1 and the closely related CEACAM5, two members of the carcinoembryonic antigen-related cell adhesion molecule family. The antibody is provided as 100 µl of unconjugated antiserum validated for western blot detection and ELISA workflows, giving labs the flexibility to detect endogenous protein in human cell lysates, tissue homogenates, and recombinant preparations without the constraints of a pre-labeled secondary system.

CEACAM1 is a transmembrane immunoglobulin-superfamily glycoprotein expressed on epithelial, endothelial, and select immune cells, where it modulates cell-cell adhesion, angiogenic signaling, and lymphocyte activation. CEACAM5, frequently referenced as CEA, is widely used as a clinical biomarker for colorectal carcinoma but is also expressed across a range of epithelial tumors and normal mucosal tissues. Dual recognition of CEACAM1 and CEACAM5 makes this polyclonal reagent a practical tool for comparative studies of these paralogs, including work on shared N-terminal Ig-like domains, glycosylation differences, and their distinct contributions to tumor progression, vascular remodeling, and innate immune evasion.

The polyclonal format offers broader epitope coverage than a monoclonal, which can be advantageous when probing full-length native antigens or isoforms with sequence variation. The unconjugated format allows end users to pair the primary antibody with HRP, biotin, fluorophore, or other reporter conjugates of their choosing. For storage and handling, follow standard IgG practice: aliquot on receipt, store at -20 °C for long-term use, refrigerate at 4 °C for short-term working stocks, and limit freeze-thaw cycles to preserve activity.