Anti-CDYL2 Antibody

The CDYL2 (Chromodomain Y-Like 2) protein is a histone crotonyltransferase that has emerged as a significant target in epigenetics and chromatin biology research. This unconjugated, affinity-purified antibody from Antibodies.com is raised in rabbit and validated for western blot, immunohistochemistry, immunocytochemistry, and ELISA applications on human samples. Researchers investigating spermatogenesis, neuronal differentiation, and cancer pathways have used CDYL2-targeting reagents to study histone crotonylation dynamics and gene silencing mechanisms.

Each vial is supplied at 100 µl, suitable for chromatin immunoprecipitation studies and broader chromatin modification workflows. The polyclonal format allows recognition of multiple epitopes across the target, supporting reproducible detection in standard immunoblotting and immunostaining protocols. Storage at standard short-term refrigeration is recommended; avoid repeated freeze-thaw cycles to preserve antibody activity.

CDYL2 has been linked to transcriptional repression and has been characterized in studies of male germ cell development, brain development, and several malignancies including breast cancer. Scientists working on histone post-translational modifications beyond methylation, such as crotonylation, will find this reagent useful for probing CDYL2 expression patterns and subcellular localization in fixed tissue sections and cultured cell preparations.