Anti-CDY1 Antibody

Rabbit polyclonal IgG raised against Chromodomain Y-linked 1 (CDY1), a testis-restricted histone acetyltransferase (EC 2.3.1.48) encoded on the Y chromosome that catalyzes histone H4 hyperacetylation in maturing spermatids during the histone-to-protamine transition. This unconjugated Antibodies.com primary reagent is supplied as a 200 µl liquid aliquot and is validated for Western blot detection of endogenous CDY1 in human, mouse, and rat samples.

The antibody supports comparative studies of Y-linked chromatin regulators across species, including rodent models of Y-chromosome gene function and investigations of male infertility linked to CDY1 deletions. Researchers apply it to testis lysates and enriched germ cell fractions to assess CDY1 protein levels, and to probe how disruption of this chromatin modifier contributes to azoospermia and spermatogenic failure.

For blotting workflows, the reagent is used on PVDF or nitrocellulose membranes with chemiluminescent or fluorescent secondary detection. Store the vial at -20 °C, protect from light, and divide into working aliquots to limit freeze-thaw cycles before each immunodetection experiment.