Anti-CDKN1A (phospho T145) Antibody

Affinity-purified polyclonal reagent raised in rabbit against a phosphorylated epitope of CDKN1A, the cyclin-dependent kinase inhibitor p21. The immunogen targets threonine 145, a residue whose modification has been linked to PI3K/Akt signaling and to cytoplasmic relocalization of p21 in stressed or growth-factor-stimulated cells. Supplied as an unconjugated IgG preparation at 200 µl per vial, it is validated for immunohistochemistry on formalin-fixed, paraffin-embedded human tissue, where it supports studies of cell-cycle exit, DNA damage response, and tumor-suppressor signaling. Researchers use this antibody to distinguish the activated, Akt-phosphorylated pool of p21 from total CDKN1A, which is particularly informative in cancer biology, vascular injury models, and investigations of cellular senescence. The unconjugated format gives flexibility to pair it with a secondary detection reagent and chromogen of the experimenter's choice, supporting both chromogenic and fluorescence workflows on sections where phospho-specific discrimination matters. Produced and quality-controlled by Antibodies.com for use in research applications involving human samples.