Anti-Cdk8 Antibody

The Antibodies.com Anti-Cdk8 polyclonal reagent targets Cyclin-dependent kinase 8, a roughly 53 kDa serine/threonine kinase that sits within the CDK8 module of the Mediator complex and regulates RNA polymerase II transcription. Supplied as 100 µl of unconjugated antiserum raised in rabbit, this Primary Antibody is validated for western blot (WB), immunohistochemistry (IHC), and ELISA workflows, with reactivity confirmed against human and mouse samples.

CDK8 pairs with cyclin C, MED12, and MED13 to form the four-subunit kinase module that reversibly docks onto the core Mediator, modulating transcription initiation and downstream signaling through WNT/β-catenin and NOTCH pathways. Research groups working on colorectal cancer, breast cancer, melanoma, and acute myeloid leukemia models commonly apply this reagent to probe CDK8 protein levels, super-enhancer biology, and the rewiring of transcriptional programs that drive oncogenesis.

As a polyclonal reagent, the antiserum recognises multiple epitopes across the CDK8 protein, which improves the likelihood of detecting alternative splice isoforms and partially degraded fragments. Aliquot on arrival to limit freeze-thaw cycling, protect the vial from light, and reserve for research use only in vitro or in vivo experimental systems.