Anti-CDK7 Antibody

This Rabbit polyclonal antibody targets Cyclin-Dependent Kinase 7 (CDK7), a serine/threonine kinase that operates as the CDK-activating kinase (CAK) within the TFIIH transcription and DNA-repair complex. The unconjugated reagent is supplied by Antibodies.com at 100 µl per vial and has been validated for Western blot (WB) and immunofluorescence (IF) workflows.

CDK7 phosphorylates the T-loop of cell-cycle CDKs (CDK1, CDK2, CDK4, CDK6) to support G1/S and G2/M progression, and it also phosphorylates the C-terminal domain of RNA polymerase II, coupling transcription initiation to cell-cycle control. Raised in Rabbit, this polyclonal reagent recognizes endogenous CDK7 in Human, Mouse, and Rat samples, enabling studies of transcriptional regulation, nucleotide excision repair, and tumor cell proliferation.

For Western blot analysis, CDK7 typically migrates near 40 kDa; immunofluorescence staining localizes the kinase to nuclear compartments, consistent with its association with TFIIH. The unconjugated format permits flexible pairing with secondary antibodies or custom fluorophore labelling, supporting immunoblotting and IF-based colocalization studies as research use only applications in cancer biology and cell-cycle checkpoint research.