Anti-CDK6 Antibody

This polyclonal reagent from Antibodies.com targets Cyclin-Dependent Kinase 6 (CDK6), a serine/threonine kinase that partners with cyclin D1 and D3 to phosphorylate the retinoblastoma (Rb) tumor suppressor and drive G1-to-S phase cell-cycle progression. Raised in rabbit and supplied as an unconjugated 100 µl aliquot at 1 mg/ml in PBS with 0.1% Sodium Azide and 50% Glycerol, the antibody is validated for Western blot, immunohistochemistry, and immunofluorescence workflows across human, mouse, and rat samples.

CDK6 is a focal point in oncology research, where its dysregulation contributes to unchecked proliferation in melanoma, glioblastoma, acute lymphoblastic leukemia, and certain B-cell lymphomas. Investigators working on cell-cycle re-entry, Rb/E2F pathway signaling, and senescence-associated chromatin remodeling use this reagent to localize CDK6 in tissue sections and detect endogenous protein in whole-cell lysates. For best results, store at -20 °C in single-use aliquots to limit freeze-thaw cycles, with short-term handling kept at 4 °C. Intended for research use only; not validated for diagnostic or therapeutic applications.