Anti-CDK6 Antibody

CDK6 is a cyclin-dependent kinase that drives the G1-to-S phase transition of dividing cells, where it typically partners with D-type cyclins (CCND1, CCND2, CCND3) to phosphorylate Rb-family proteins and commit cells to DNA replication. This unconjugated rabbit polyclonal primary antibody from Antibodies.com recognises CDK6 and has been validated for western blot and immunohistochemistry on human and rat samples. The 100 µl volume is supplied as a research-use-only reagent for studies of cell-cycle control, hematopoietic lineage commitment, and tumor biology, including malignancies such as glioblastoma, melanoma, and B-cell acute lymphoblastic leukemia where CDK6 is frequently amplified, translocated, or otherwise dysregulated. In IHC, the reagent can be paired with HRP- or biotin-conjugated secondary antibodies and revealed with DAB or other chromogenic substrates; in WB, an anti-rabbit IgG-HRP secondary yields detection of the ~40 kDa CDK6 band. Store refrigerated; avoid repeated freeze-thaw cycles to preserve antibody activity across multiple experiments.