Anti-CDK6 (Ab-24) Antibody

Produced in rabbit as a polyclonal antiserum by Antibodies.com, this primary antibody recognizes cyclin-dependent kinase 6 (CDK6), a serine/threonine kinase that partners with D-type cyclins to drive the G1 to S phase transition by phosphorylating the retinoblastoma tumor suppressor. The Ab-24 epitope maps to a region encompassing tyrosine 24 of CDK6, a residue targeted by Src family kinases, supporting studies of mitogenic signaling, kinase regulation, and oncogenic transformation in cancer biology.

Validated for western blot and immunohistochemistry, this unconjugated reagent enables researchers to probe CDK6 expression and modification status across cell line panels and primary tissue lysates, and to localize CDK6 distribution in formalin-fixed paraffin-embedded sections. Demonstrated reactivity with human, mouse, and rat samples supports translational workflows spanning rodent disease models and human clinical specimens relevant to lymphoma and leukemia research.

Each vial delivers 100 µL of polyclonal antiserum suitable for standard immunodetection protocols, including overnight incubation at 4 °C with chemiluminescent or chromogenic detection. Store refrigerated at 4 °C in single-use aliquots to preserve antibody titer; this reagent is intended for research use only and pairs effectively with CDK4/6 inhibitor studies and cell cycle arrest investigations.