Anti-CDK5R1 Antibody

Raised in rabbit against Cyclin-Dependent Kinase 5 Regulatory Subunit 1 (CDK5R1), this unconjugated polyclonal antibody from Antibodies.com targets a neuron-enriched regulatory protein critical for CNS development, neuronal migration, and synaptic plasticity. CDK5R1 (also known as p35 or p23) is the principal activating partner of CDK5, and its calpain-mediated cleavage to the p25 fragment is implicated in tau hyperphosphorylation and Alzheimer's disease pathology.

The antibody is supplied as a 100 µl aliquot and validated for Western blot (WB) and immunofluorescence (IF) applications across human, mouse, and rat samples. Researchers studying neurodegeneration, cortical lamination, or neuronal differentiation use it to monitor p35/p25 expression and subcellular localization in primary neurons and brain tissue sections. The unconjugated format permits flexible secondary labeling with HRP, fluorophore, or biotin conjugates chosen to match individual imaging or blotting protocols.

For storage, aliquot the antiserum upon receipt, store refrigerated at 4 °C, and limit freeze-thaw cycles to preserve antibody titer. Each vial is supplied in a single-use volume that supports multiple experimental replicates, providing consistent detection in WB and IF workflows.