Anti-CDK5 Antibody

Raised in rabbits and affinity-purified to detect endogenous Cyclin-Dependent Kinase 5, this polyclonal IgG reagent from Antibodies.com is supplied as 100 µl of unconjugated antibody in a liquid vial format. The antibody recognizes the 33 kDa CDK5 kinase in human, mouse, and rat samples, enabling cross-species comparison in neuroscience and oncology workflows.

Validated for western blot and immunohistochemistry, the reagent supports both protein-level expression analysis in cell and tissue lysates and localization studies in fixed brain sections. The unconjugated format lets laboratories pair it with their own HRP, fluorescent, or biotin secondary conjugates for flexible detection chemistry.

CDK5 is unique among cyclin-dependent kinases because it is not activated by cyclins but by the neuronal partners p35 and p39, and it phosphorylates substrates such as tau and neurofilament proteins. Deregulation of CDK5/p35 signaling has been linked in published research to Alzheimer's disease models, Parkinson's models, and certain cancer cell migration studies, making this reagent broadly applicable to neurodegeneration and tumor biology research.