Anti-CDK4 Antibody

CDK4 (Cyclin-Dependent Kinase 4) is a serine/threonine kinase that partners with D-type cyclins to drive the G1 to S phase transition of the cell cycle by phosphorylating the retinoblastoma protein. This rabbit polyclonal antibody from Antibodies.com targets CDK4 and is validated for Western blot, immunohistochemistry, and immunofluorescence workflows across human, mouse, and rat samples.

CDK4 dysregulation is widely studied in oncology, including melanoma, glioblastoma, and pancreatic cancer research, where its role as a tumor driver and therapeutic target is well established. The polyclonal format enables recognition of multiple epitopes on the kinase, which can help detect different isoforms or post-translationally modified forms. Supplied as 100 µl of unconjugated antibody at 1 mg/ml in PBS with 0.1% sodium azide and 50% glycerol, the reagent is ready for direct use in western blot, IHC, and IF protocols, and is compatible with custom labeling or secondary-detection strategies.

For storage and handling, keep refrigerated at 4 degrees C for short-term use, or aliquot and freeze at -20 degrees C for longer-term storage. Avoid repeated freeze-thaw cycles to preserve antibody activity across experiments.