Anti-CDK2 Antibody

This CDK2 antibody from Antibodies.com is a rabbit polyclonal IgG reagent raised against cyclin-dependent kinase 2, the serine/threonine kinase that partners with cyclin E and cyclin A to drive the G1/S transition and S-phase progression of the cell cycle. The unconjugated antibody is supplied as a 200 µL vial and has been validated for western blotting (WB) and immunohistochemistry (IHC) on human and mouse specimens, supporting work in cell-cycle biology, Rb phosphorylation studies, and cancer signaling research where CDK2 is frequently examined as a marker of proliferative activity. The polyclonal host response provides multi-epitope recognition of the target, which is useful for tracking both unmodified and post-translationally modified forms of the kinase across denaturing gels and fixed tissue sections. Endogenous CDK2 migrates near the expected 33 kDa band in western blot, and immunostaining in proliferating tissues such as testis, thymus, and many tumor sections produces nuclear signal consistent with its role in replication-coupled processes.