Anti-CDK1 (phospho Y15) Antibody

The phospho-specific antibody from Antibodies.com targets CDK1 at the inhibitory tyrosine 15 residue, a key regulatory site controlling G2/M transition during mitosis. Raised in rabbit and purified as a polyclonal IgG preparation, the reagent is supplied unconjugated in a 50 µl vial and validated for Western blot across human, mouse, and rat samples.

Researchers studying cell cycle checkpoints, DNA damage responses, and mitotic entry use this reagent to distinguish the inactive, Y15-phosphorylated CDK1 pool from the active dephosphorylated enzyme. The unconjugated format supports flexible pairing with a wide choice of secondary antibodies, and the polyclonal nature provides robust detection of the phospho-epitope even when neighboring post-translational modifications are present. Intended for research use only, the antibody supports investigations into Wee1 and Myt1 kinase activity, Cdc25 phosphatase function, and checkpoint recovery in dividing cells, and it can be combined with total CDK1 blots to assess pathway activation state.