Anti-CDH23 Antibody

Originating from the cadherin superfamily, CDH23 (cadherin-23) assembles the tip-link filaments that connect adjacent stereocilia in cochlear and vestibular hair cells, converting mechanical sound waves into neural signals. This rabbit polyclonal IgG reagent from Antibodies.com is affinity-purified and supplied as a 50 µl aliquot of unconjugated antiserum, ready for direct incorporation into Western blot and immunohistochemistry workflows on human, mouse, and rat samples. The antibody localizes the endogenous CDH23 polypeptide across paraffin tissue sections in IHC and resolves the protein on immunoblots, supporting studies of Usher syndrome type 1D, DFNB12 autosomal recessive non-syndromic deafness, retinal photoreceptor maintenance, and hair bundle morphogenesis. To preserve lot-to-lot activity, store the vial at -20°C upon arrival, prepare single-use aliquots, and protect from repeated freeze-thaw cycles. Shipped as a liquid formulation, the reagent is intended for research use only in basic and translational hearing and vision research.