Anti-CDH23 Antibody

Cadherin-23 (CDH23) is a calcium-dependent cell-cell adhesion glycoprotein that forms part of the mechanotransduction complex in inner ear hair cells and contributes to photoreceptor maintenance in the retina. This unconjugated rabbit polyclonal IgG reagent from Antibodies.com was raised against CDH23 and is validated for western blot (WB) and immunohistochemistry (IHC) workflows, with demonstrated reactivity to Human, Mouse, and Rat samples.

Supplied as 200 µl of liquid antibody, the reagent tolerates standard short-term handling at refrigerated temperatures and is intended for research applications in auditory biology, vision science, and Usher syndrome studies. The polyclonal format offers broader epitope coverage than a monoclonal reagent, supporting detection of multiple regions of the cadherin-23 protein across species.

Typical working concentrations depend on detection chemistry: western blot bands are commonly visualized using HRP-conjugated secondary antibodies, while IHC on fixed tissue sections benefits from antigen retrieval optimized for formalin-fixed paraffin-embedded specimens. Researchers investigating tip links, stereocilia organization, or retinal degeneration pathways rely on this reagent to map native CDH23 distribution across model systems.