Anti-CDC5L Antibody

Raised in rabbit against the human CDC5L (Cell Division Cycle 5-Like) protein, this unconjugated polyclonal antibody from Antibodies.com targets an approximately 92-kDa splicing factor that forms the catalytic core of the PRP19–CDC5L complex, also called the NineTeen Complex (NTC), within the active spliceosome. The reagent is supplied as 100 µl of liquid and is validated for Western Blot and Immunohistochemistry applications on samples derived from human, mouse, and rat tissue. CDC5L drives the activation step of pre-mRNA splicing and supports G2/M progression through mitosis, so the antibody is frequently used to study spliceosome assembly, cell-cycle checkpoints, the DNA damage response, and transcriptional regulation in primary cells and established lines. Because it is polyclonal, the reagent recognizes multiple epitopes on the target, which improves robustness under varied fixation, lysis, and antigen-retrieval conditions typical of tissue-section and whole-cell lysate workflows. Aliquot upon arrival and store refrigerated; avoid repeated freeze-thaw cycles to preserve activity across multiple experiments.