Anti-CDC2 Antibody

This polyclonal rabbit antibody from Antibodies.com targets CDC2, a serine/threonine kinase also known as CDK1 that serves as the master regulator of mitotic entry and cell cycle progression through G1/S and G2/M phase transitions. The unconjugated reagent is supplied as a 100 µl volume and is validated for Western blot and immunofluorescence workflows across human, mouse, and rat samples.

CDC2 partners with cyclin A and cyclin B to phosphorylate substrates such as histone H1, the retinoblastoma protein, and lamins, driving the structural and biochemical changes required for chromosome condensation, nuclear envelope breakdown, and spindle assembly. Investigators studying cell division, checkpoint control, DNA damage response, and cancer biology use CDC2 detection to track proliferative status and mitotic commitment in fixed cells and lysate preparations.

Raised in rabbit as a polyclonal reagent, this antibody recognizes multiple epitopes on the CDC2 target, which can strengthen signal recovery when expression is low or when partial proteolysis has occurred. The unconjugated format allows pairing with a custom secondary label of choice, including HRP, fluorophore conjugates, or biotin, depending on the chosen readout. Storage and handling notes accompany the vial to preserve activity across repeated freeze-thaw cycles.