Anti-CDC14A Antibody

Produced in rabbit as an unconjugated polyclonal IgG preparation, this CDC14A-targeting reagent from Antibodies.com is supplied as a 100 µL vial for research use only and is validated across western blot, immunohistochemistry, and flow cytometry workflows. Reactivity is reported against human and mouse samples, supporting studies in cell-cycle biology where CDC14A, a dual-specificity phosphatase of the protein tyrosine phosphatase family, governs centrosome separation, mitotic exit, and the DNA-damage response. Investigators tracking aberrant chromosome segregation, primary cilia dynamics, or the phosphatase's context-dependent links to tumor suppression and proliferation typically pair this reagent with lysates from cycling cells, where CDC14A abundance and phosphorylation shift with mitotic stage. The polyclonal format broadens epitope coverage across the phosphatase domain and flanking regions, an advantage when probing post-translational modification states or comparing isoforms in patient-derived tissue sections by IHC. Aliquot on receipt and store frozen to limit the number of freeze-thaw cycles; protect from light during handling. Pair with appropriate secondary antibodies for detection, since the conjugate is unconjugated and the host species is rabbit.