Anti-CD95/FAS (phospho-Y291) Antibody

Raised against the phosphorylated tyrosine 291 residue of human CD95 (FAS/APO-1), this unconjugated rabbit polyclonal reagent from Antibodies.com supports apoptosis and death-receptor signaling research. Supplied at 1 mg/ml in PBS with 0.1% sodium azide and 50% glycerol as a 100 µl vial, the antibody is validated for Western blot detection of the activated FAS receptor in human samples. The phospho-Y291 modification maps to the cytoplasmic death domain, where it influences recruitment of FADD and procaspase-8 into the death-inducing signaling complex (DISC). Researchers apply this reagent to tumor cell lysates, activated T-cell models, and tissue samples to probe FAS activation state, DISC assembly, and downstream caspase-8 cleavage events relevant to immune tolerance, autoimmunity, and chemotherapy-induced apoptosis.