Anti-CD86 Antibody [Assigned #A10795]

This unconjugated monoclonal rabbit IgG antibody targets CD86, a type-I transmembrane glycoprotein of the B7 costimulatory family that is constitutively or inducibly expressed on professional antigen-presenting cells, including dendritic cells, macrophages, and activated B cells. By engaging CD28 and CTLA-4 on T lymphocytes, CD86 delivers the second signal required for productive T cell activation, making anti-CD86 reagents essential tools for mapping costimulatory pathways in immunology research. Antibodies.com supplies this reagent as 200 µl of antibody suitable for Western blot, immunohistochemistry, immunofluorescence, and immunoprecipitation workflows.

Clone A10795 was raised in rabbits and validated against human and rat samples, supporting cross-species studies of antigen presentation, immune checkpoint biology, and inflammatory disease. Researchers investigating tumour microenvironments, transplant rejection, autoimmune inflammation, dendritic cell maturation, and infectious disease models routinely use anti-CD86 antibodies to track receptor expression on antigen-presenting cells in tissue sections and to follow activation-induced changes after stimulation. The unconjugated format allows flexible pairing with HRP, biotin, fluorophore, or chromogen-labelled secondary reagents selected by the user, and the antibody can be applied to both fresh-frozen and paraffin-embedded specimens, depending on the chosen detection chemistry.