Anti-CD86 Antibody

Produced in rabbit and affinity purified against the human B7-2 co-stimulatory protein, this unconjugated polyclonal reagent from Antibodies.com detects CD86 on the surface of antigen-presenting cells, including dendritic cells, macrophages, and activated B lymphocytes. It is validated for western blot, immunohistochemistry, immunofluorescence, and immunoprecipitation workflows.

CD86 engages CD28 and CTLA-4 on T lymphocytes to deliver the second signal required for full T cell activation, making antibodies against this target widely used in studies of transplant rejection, autoimmune disease, checkpoint immunotherapy, and tumor microenvironment immunology. Researchers characterizing dendritic cell maturation or co-stimulatory signaling often rely on this reagent to track B7-2 expression across tissues and cell populations.

The antibody is supplied as 100 µl of polyclonal antiserum in a single-use vial, unconjugated so it can be paired with fluorophore-, enzyme-, or biotin-labeled secondary reagents for flexible detection chemistry. Reactivity is reported for human CD86, with each lot qualified to support reproducible staining and immunoblotting of the native glycoprotein in cell lysates and fixed tissue sections. Refrigerated storage preserves activity for routine benchtop handling.