Anti-CD80 Antibody

This Antibodies.com rabbit polyclonal antibody specifically targets CD80 (also known as B7-1), a 60-80 kDa type I transmembrane glycoprotein that delivers co-stimulatory signaling during T lymphocyte activation by engaging CD28 and CTLA-4. CD80 is inducibly expressed on the surface of professional antigen-presenting cells such as dendritic cells, activated B lymphocytes, and macrophages, making it a widely used marker of APC maturation and immune regulation studies.

Supplied as 100 µg of unconjugated IgG in a vial, this reagent is validated for Western blot (WB) detection of human CD80. For long-term stability, aliquot the antibody upon arrival, store at -20 °C, and limit freeze-thaw cycles. Researchers use this reagent to explore co-stimulatory checkpoint biology, transplant tolerance, autoimmune models, and tumor immune microenvironment characterization.