Anti-CD74 Antibody

The CD74 protein, also known as the MHC class II invariant chain, serves as a chaperone that directs MHC class II molecules through the endosomal peptide-loading pathway and acts as a cell-surface receptor for macrophage migration inhibitory factor. This unconjugated rabbit polyclonal reagent from Antibodies.com is raised against human CD74 and is validated for Western blot and ELISA workflows, supporting investigations of antigen presentation, B-cell maturation, and receptor-mediated signaling. The antibody is supplied as 100 µl of polyclonal antiserum and is intended for use with samples derived from professional antigen-presenting cells, including B lymphocytes, monocytes, macrophages, and dendritic cells. Researchers examining aberrant CD74 expression in gastric adenocarcinoma, pancreatic carcinoma, renal cell carcinoma, or select B-cell lymphomas can apply the reagent to characterize protein levels in cell lysates and recombinant preparations. Store refrigerated, protect from light, and aliquot to limit freeze-thaw cycles in order to preserve binding activity.