Anti-CD70 Antibody

Raised in rabbit and supplied as an unconjugated polyclonal reagent in a 100 µl vial, this Antibodies.com antibody recognizes human CD70, a type II transmembrane glycoprotein of the TNF superfamily that acts as the ligand for CD27 on T and B lymphocytes. The reagent is validated for Western blot and ELISA workflows on human samples, where CD70 detection supports studies of costimulatory signaling, germinal center B-cell biology, and immune checkpoint regulation.

CD70 expression is normally restricted to activated T cells, B cells, NK cells, and mature dendritic cells, but is frequently upregulated in renal cell carcinoma, glioblastoma, and several non-Hodgkin lymphomas, where the marker has been explored as a therapeutic and imaging target. For best results, refrigerate the vial, protect it from light, and avoid excessive freeze-thaw cycles by aliquoting on first use.