Anti-CD59 Antibody

This unconjugated rabbit polyclonal reagent from Antibodies.com targets CD59, a glycosylphosphatidylinositol-anchored cell surface glycoprotein that restricts assembly of the complement membrane attack complex (C5b-9) on host cells. The antibody is raised in rabbit and supplied at 100 µl per vial, ready for dilution into western blot and ELISA workflows.

Researchers apply this reagent to detect human CD59 in cell lysates and tissue extracts by immunoblotting and to quantify the antigen in immunoassays. Acquired CD59 deficiency on hematopoietic stem cells, caused by PIGA mutations, drives paroxysmal nocturnal hemoglobinuria, so the antibody is widely used to study complement regulation, glycosylphosphatidylinositol-anchor biosynthesis, and expression of cell-surface complement regulatory proteins on peripheral blood cells and cultured lines.

Reactivity is reported against human CD59 in the product specification. Store refrigerated; aliquot upon arrival to limit freeze-thaw cycles and preserve antibody activity. Supplied for research use only, not intended for diagnostic or therapeutic applications.