Anti-CD59 Antibody

Manufactured by Antibodies.com, this polyclonal reagent is raised in rabbit against the human CD59 glycoprotein and is supplied as an unconjugated, affinity-purified antiserum at a working concentration of 1.0 mg/mL. The 50 µL format is formulated in phosphate-buffered saline (without Mg²⁺ and Ca²⁺) at pH 7.4, containing 150 mM sodium chloride, 0.02% sodium azide as a preservative, and 50% glycerol to protect the protein during storage, typically at –20 °C for long-term stability. The immunogen used to generate the antibody is a recombinant human CD59 protein, and the product is purified by affinity chromatography against that immunogen to ensure batch-to-batch consistency. Validated applications include Western Blotting and Immunohistochemistry, where the reagent detects endogenous levels of total CD59 in human, mouse, and rat samples, making it a versatile choice for cross-species studies of complement regulation, glycosylphosphatidylinositol-anchored cell-surface proteins, and membrane attack complex inhibition. With its polyclonal clonality and unconjugated state, the antibody offers broad epitope coverage and can be paired with secondary reporters of the researcher's choice, such as HRP-, fluorophore-, or biotin-conjugated anti-rabbit IgG reagents. It is intended for research use only and is not cleared for diagnostic or therapeutic applications. Researchers investigating CD59 expression in normal versus pathological tissues—including studies of autoimmune disease, cancer immune evasion, paroxysmal nocturnal hemoglobinuria, and ischemic injury—will find this reagent a reliable tool for both membrane-protein biochemistry and tissue-section imaging workflows.