Anti-CD44 Antibody

CD44 is a transmembrane glycoprotein that serves as the principal cell surface receptor for hyaluronic acid, with documented roles in lymphocyte activation, cell-cell adhesion, cell migration, and tumor progression across multiple cancer types. This rabbit polyclonal antibody from Antibodies.com is validated for Western blot and immunohistochemistry workflows, detecting the standard CD44 isoform in human, mouse, and rat samples.

The unconjugated format provides flexibility for downstream conjugation with fluorophores, horseradish peroxidase, or biotin depending on the chosen detection strategy. Supplied as a 100 µl vial, the polyclonal antibody recognizes multiple epitopes on the target protein, supporting detection across a range of expression levels and helping compensate for epitope masking by post-translational modifications.

Research applications include characterization of cancer stem cell populations, investigation of leukocyte trafficking, analysis of hematopoietic stem and progenitor cells, and studies of extracellular matrix interactions. The cross-reactivity profile across human, mouse, and rat enables direct comparative studies between rodent disease models and human clinical specimens in oncology, inflammation, and tissue remodeling research.