Anti-CD40 Ligand Antibody

This polyclonal antibody from Antibodies.com targets CD40 Ligand (CD40L/CD154), a type II transmembrane TNF-family member expressed on activated CD4+ T cells, platelets, and other immune cells where it engages CD40 on B lymphocytes, dendritic cells, and macrophages. Raised in rabbit and supplied unconjugated at 1 mg/ml in PBS with 0.1% sodium azide and 50% glycerol, the 50 µl reagent is intended for Western blot detection across human, mouse, and rat samples.

CD40L is a roughly 39 kDa glycoprotein best known for driving immunoglobulin class switching and germinal center formation, and loss-of-function mutations are linked to X-linked Hyper-IgM syndrome. Researchers use this reagent to probe CD40L expression in lymphocyte co-culture assays, vascular inflammation models, and transplant rejection studies, and the polyclonal format increases the chance of recognizing denatured epitopes on Western blots. Aliquot upon receipt to minimize freeze-thaw cycles and store frozen at -20°C, protected from light, to preserve antibody activity.