Anti-CD40 Antibody

This polyclonal reagent from Antibodies.com targets the CD40 co-stimulatory receptor, a 48 kDa member of the TNF receptor superfamily expressed on B lymphocytes, dendritic cells, macrophages, and other antigen-presenting cells. CD40 ligation by CD154 drives NF-κB signaling, B cell proliferation, germinal center formation, and immunoglobulin class-switch recombination, making this marker a widely used tool in studies of adaptive immunity and immune checkpoint biology.

The unconjugated preparation is supplied as 100 µl of antiserum raised in rabbit and is validated for western blot and immunohistochemistry on human tissue. Store the vial refrigerated and aliquot to limit freeze-thaw cycles, protecting the solution from light to preserve antibody activity. Researchers working on X-linked hyper-IgM syndrome, lymphoma phenotyping, tumor microenvironment staining, or B cell activation pathways commonly apply anti-CD40 antibodies in flow cytometry panels and IHC protocols on tonsil and spleen sections.