Anti-CD284 Antibody

This rabbit polyclonal antibody targets CD284, the surface glycoprotein also known as Toll-like receptor 4 (TLR4), a pattern recognition receptor central to innate immune signaling. Produced by Antibodies.com as an unconjugated polyclonal reagent supplied in a 100 µl volume, it is validated for Western blot, immunohistochemistry, and ELISA workflows across human and mouse sample types. TLR4 sits on the plasma membrane of macrophages, monocytes, dendritic cells, and select epithelial populations, where it recognizes bacterial lipopolysaccharide and initiates MyD88- and TRIF-dependent cascades that drive NF-κB activation and downstream cytokine release. Researchers studying endotoxin response, sepsis pathophysiology, chronic inflammatory disease, and host-pathogen interactions rely on anti-CD284 reagents to map receptor expression in tissue sections, track protein levels in cell lysates, and quantify soluble or cell-associated TLR4 by ELISA. The polyclonal format offers broader epitope coverage than a monoclonal clone, supporting consistent detection across denatured and native preparations, and the unconjugated format gives laboratories full flexibility to pair the antibody with their own HRP, biotin, or fluorophore labels for downstream assay development.