Anti-CD274 Antibody

PD-L1 (programmed death-ligand 1, also called CD274 or B7-H1) is a type I transmembrane immune checkpoint protein and a member of the B7 family of costimulatory molecules. Its engagement with PD-1 on activated T lymphocytes delivers an inhibitory signal that dampens T-cell receptor-mediated responses, and CD274 expression on tumor and stromal cells is a well-characterized mechanism of adaptive immune resistance that makes this target a focal point of checkpoint blockade research.

This unconjugated rabbit polyclonal IgG preparation is supplied by Antibodies.com at 1 mg/ml in phosphate buffered saline (PBS) containing 0.05% sodium azide at approximately pH 7.3, and is validated for western blot detection of endogenous CD274 in human, mouse, and rat samples. The 100 µl vial format suits exploratory immunoblotting of cell lysates and tissue homogenates, while the polyclonal format offers broad recognition of multiple epitopes within the target protein for flexible assay development.