Anti-CD244 Antibody

Produced in rabbit as a polyclonal reagent, this unconjugated antibody from Antibodies.com targets human CD244, a SLAM-family receptor best characterized on natural killer cells, CD8+ cytotoxic T lymphocytes, gamma-delta T cells, and selected myeloid subsets. Each vial contains 100 µl of antisera validated for Western blot and ELISA workflows, giving end-users the flexibility to conjugate the antibody to HRP, biotin, or a chosen fluorophore. CD244 (also called 2B4 or SLAMF4) binds the ligand CD48 and modulates both activating and inhibitory signals during NK-cell education, antiviral responses, and tumor surveillance, so researchers apply this reagent to study innate immune signaling, SLAM-receptor crosstalk, and the activation thresholds of effector lymphocytes. The polyclonal format allows recognition of multiple epitopes on the CD244 ectodomain, supporting detection of native and denatured target in cell lysates, primary peripheral blood mononuclear cell preparations, and relevant human cell lines such as NK-92. The rabbit host minimizes spectral overlap when combined with mouse monoclonals in multi-color flow cytometry panels, and the unconjugated format leaves labeling choices to the investigator. Reactivity is directed against the human protein, and the reagent is intended for research use only.