Anti-CD130 Antibody

Rabbit polyclonal antibody targeting CD130 (gp130 / IL6ST), the signal-transducing subunit shared by receptors for the IL-6 cytokine family. Raised in rabbit and supplied as 100 µl of unconjugated antiserum, this Antibodies.com reagent is validated for western blot, immunohistochemistry, immunofluorescence, and ELISA workflows on human and mouse samples.

CD130 is a type I transmembrane glycoprotein that couples ligand binding to JAK1, JAK2, and STAT3 signalling, making it a relevant marker in studies of inflammation, acute-phase response, B-cell differentiation, and tumour microenvironment biology. The polyclonal format broadens epitope coverage across the cytoplasmic and extracellular regions, useful when monoclonal clones give weak signal or when probing truncated isoforms.

Researchers working on IL-6, IL-11, LIF, or oncostatin-M pathways, gp130-dependent STAT activation, or membrane versus soluble CD130 distribution can apply this antibody to whole-cell lysates, fixed tissue sections, and cultured cell monolayers. Each vial is provided unconjugated, allowing flexible downstream labelling or direct use in standard immunodetection buffers.