Anti-CD11B Antibody

For research on myeloid cell populations, this rabbit polyclonal reagent from Antibodies.com targets CD11B (also called ITGAM, the alpha-M subunit of complement receptor 3 / Mac-1), the beta-2 integrin that pairs with CD18 to mediate leukocyte adhesion, chemotaxis, and phagocytosis of iC3b-opsonized material. Supplied as 100 µl of unconjugated antibody at 1 mg/ml in PBS with 0.1% sodium azide and 50% glycerol as a cryoprotectant, the reagent is validated for Western blot and immunohistochemistry on human tissue and cell samples. CD11B expression marks monocytes, macrophages, granulocytes, and NK cells, and the antibody is used to profile tumor-associated macrophages, microglia in neuroscience, and inflammatory infiltrates in disease models. The polyclonal format gives multi-epitope recognition of the integrin, useful when monoclonal antibodies give weak signal in IHC or WB. Aliquot upon arrival to limit freeze-thaw cycles, store refrigerated, and protect from light for long-term stability.