Anti-CD107a Antibody

The CD107a antigen, also known as LAMP-1 (Lysosomal-Associated Membrane Protein 1), is a heavily glycosylated type I transmembrane protein anchored in the lysosomal limiting membrane of virtually all nucleated mammalian cells. When cytotoxic lymphocytes engage a target, perforin- and granzyme-bearing lysosome-related granules fuse with the plasma membrane and translocate CD107a to the outer leaflet, a process that has made CD107a the most widely validated cell-surface marker of degranulation for NK cells and CD8+ cytotoxic T lymphocytes in immunological assays.

This Rabbit polyclonal Anti-CD107a Antibody from Antibodies.com is supplied unconjugated in a 100 µl volume, with reactivity confirmed against human and rat samples and validation for western blot and ELISA workflows on cell and tissue lysates. Raised in rabbit against the native target, the polyclonal reagent offers batch-to-batch consistency for longitudinal studies of CTL and NK cell effector function, lysosomal trafficking, and plasma-membrane repair pathways. Researchers apply the antibody to probe CD107a/LAMP-1 expression in cell culture-derived samples, primary immune-cell isolates, and biochemical extracts prepared from tumor, immune, and neural tissue backgrounds.