Anti-CCNE1 Antibody

The polyclonal reagent from Antibodies.com targets Cyclin E1 (CCNE1), a nuclear protein that partners with cyclin-dependent kinase 2 (CDK2) to drive the G1-to-S phase transition of the cell cycle. CCNE1 accumulation promotes initiation of DNA replication and centrosome duplication, and aberrant overexpression has been documented in breast, ovarian, and endometrial carcinomas, where it serves as a marker of proliferative drive and genomic instability in tumor biology.

Raised in rabbit and supplied as 200 µl of unconjugated IgG, the antibody is validated for Western blot, immunohistochemistry, and flow cytometry on human samples, giving laboratories a single reagent for protein-level readouts across lysate, tissue section, and suspended-cell workflows. Researchers studying cell-cycle deregulation, oncogenic signalling, or proliferation pathways commonly apply it to monitor CCNE1 abundance alongside CDK2 and other G1/S regulators, using the unconjugated format to pair with secondary detection chemistries of their choice.