Anti-CCND2 Antibody

Cyclin D2 (encoded by the CCND2 gene) is a key regulator of the G1-to-S phase transition in the cell cycle, and this rabbit polyclonal IgG reagent from Antibodies.com provides a research-use tool for detecting endogenous human CCND2 protein by Western blot. The unconjugated antibody is supplied at 50 µl per vial, affinity-purified and ready for direct use in standard SDS-PAGE workflows.

The CCND2 locus maps to chromosome 12p13 and is expressed in a restricted set of human tissues, including ovary, testis, and certain neural populations, which makes a human-reactive reagent particularly useful for studies of cell-cycle re-entry, neuronal progenitor proliferation, and gonadal development. Researchers investigating cyclin D-dependent kinase activity and CDK4/6 partnerships often pair this antibody with CCND1 and CCND3 reagents to compare isoform-specific expression across matched lysates.

For Western blot applications, use reducing conditions and chemiluminescent or fluorescent detection; optimization of blocking and primary incubation times is advised given the polyclonal nature of the product. Aliquoting upon first use helps preserve performance across multiple freeze-thaw cycles, and the vial should be stored refrigerated for short-term handling according to manufacturer's guidance.

This reagent is intended for research use only, supporting basic and translational projects that explore cyclin D2 biology in human cells and tissue lysates.