Anti-CCND1 (phospho T286) Antibody

Raise detection of phosphorylated cell-cycle regulators with this polyclonal reagent from Antibodies.com that recognizes Cyclin D1 (CCND1) when phosphorylated at threonine 286. The antibody is raised in rabbit, prepared as a polyclonal IgG, supplied unconjugated in a 100 µl vial, and validated for Western blot application on human samples. Threonine 286 phosphorylation is a well-characterized regulatory event that triggers nuclear export of Cyclin D1 and its subsequent ubiquitin-dependent proteasomal degradation, linking this epitope to G1/S checkpoint control, GSK3β signaling, and oncogenic proliferation pathways. Researchers studying breast cancer, mantle cell lymphoma, and other proliferative disorders can use the reagent to monitor the post-translationally modified form of CCND1 in cell lysates and tissue homogenates. The polyclonal response against the phospho-peptide supports broad recognition of the modified target across varied blot conditions, enabling studies of mitogen-driven cell cycle progression, DNA damage responses, and therapeutic modulation of Cyclin D1 stability.