Anti-CCND1 Antibody

CCND1 encodes cyclin D1, a nuclear regulatory protein that drives the G1 to S phase transition of the cell cycle through partnership with cyclin-dependent kinases CDK4 and CDK6. Aberrant cyclin D1 expression is a recognized hallmark of several malignancies, including mantle cell lymphoma, multiple myeloma, and subsets of breast and colorectal cancer, which makes this antigen a focal target in oncology research and diagnostic pathology studies.

This unconjugated rabbit polyclonal reagent is supplied by Antibodies.com as a 100 µL liquid aliquot validated for western blot and immunohistochemistry workflows. The antibody detects endogenous cyclin D1 in human, mouse, and rat samples, supporting investigation of proliferative signaling, Rb pathway status, and tumor grading in fixed tissue sections and prepared cell lysates. Researchers commonly pair it with a nuclear counterstain for IHC, or with appropriate horseradish peroxidase- or fluorophore-conjugated secondary antibodies for chemiluminescent or fluorescent western blot detection.

Each preparation is affinity-purified from rabbit serum and quality-validated for routine laboratory use. Storage at -20 °C in working aliquots helps preserve activity and limit freeze-thaw cycles across extended studies of cell cycle regulation and tumor biology.