Anti-CBX8 Antibody

Raised in rabbit against the chromobox 8 (CBX8) protein, this polyclonal IgG reagent from Antibodies.com is supplied as a 50 µl liquid aliquot for chromatin and gene-regulation studies. CBX8 is a reader subunit of canonical Polycomb Repressive Complex 1 that recognizes the H3K27me3 histone mark placed by PRC2 and helps maintain transcriptional silencing at developmental loci, including Hox gene clusters, making the antibody a useful probe for PRC1 recruitment, X-inactivation, and tumor suppressor regulation in cancer epigenetics research.

Affinity-purified from rabbit antiserum and validated for Western blot and immunohistochemistry on human, mouse, and rat samples, the unconjugated reagent detects endogenous CBX8 in nuclear extracts and fixed tissue sections. The polyclonal format recognizes multiple epitopes on the target, which improves signal recovery when epitope accessibility is variable across fixation conditions. For short-term handling the vial should be refrigerated; for long-term storage aliquot and freeze at -20°C to limit freeze-thaw damage, and the reagent is intended for research use only.