Anti-CBX5 Antibody [Assigned #A10612]

This mouse monoclonal IgG antibody from Antibodies.com recognizes CBX5 (Chromobox protein homolog 5), also known as HP1α, a chromodomain-containing reader of the histone H3 Lys9 trimethylation mark that recruits repressive chromatin complexes to pericentric heterochromatin and is implicated in the DNA damage response, telomere maintenance, and transcriptional silencing.

The unconjugated reagent is supplied in a 50 µL vial and is validated for western blot and immunohistochemistry workflows. Cross-reactivity has been demonstrated against human, mouse, and rat samples, supporting comparative chromatin studies across mammalian model systems. Researchers commonly use this clone to probe heterochromatin organization in cell lysates by WB and to visualize nuclear HP1α foci in fixed tissue sections by IHC.

CBX5 localizes predominantly to nuclear heterochromatin and shows dynamic redistribution during differentiation, cellular senescence, and genotoxic stress. Interpreting IHC staining patterns alongside WB band intensity allows investigators to track chromatin-state transitions in primary samples and cultured cells.