Anti-CBX4 Antibody

CBX4 (Chromobox protein 4) is a Polycomb group protein that operates both as a transcriptional repressor within PRC1 and as an E3 SUMO ligase in chromatin-associated complexes. The Antibodies.com rabbit polyclonal reagent is supplied as a 100 µl vial of unconjugated antiserum validated for Western blot and immunofluorescence detection of the human and mouse protein. In research applications, the antibody supports studies of H3K27me3 recognition through the chromodomain, SUMOylation of nuclear substrates such as DNMT3A and CtBP1, and Polycomb-mediated gene silencing during differentiation and the DNA damage response. Users commonly pair this primary reagent with HRP- or fluorophore-conjugated secondaries to visualize endogenous CBX4 in whole-cell lysates, nuclear extracts, and fixed-cell preparations. Aliquot upon receipt and refrigerate to limit freeze-thaw cycles and preserve binding activity across long-term studies.