Anti-CBX4 Antibody

Housing an unconjugated polyclonal reagent from Antibodies.com, this rabbit host IgG reagent targets CBX4 (Chromobox 4), a Polycomb group PRC1 component that acts as an E3 SUMO ligase and reads histone H3K27me3 marks through its N-terminal chromodomain. Validated for western blot, immunohistochemistry, and immunoprecipitation workflows on human and mouse samples, the 200 µL liquid aliquot supports studies of chromatin remodeling, transcriptional repression, and PcG nuclear body composition. Aliquot the antibody upon arrival and store refrigerated to preserve activity across multiple experiments, minimizing freeze-thaw cycles to maintain consistent titer. Researchers examining PRC1-mediated gene silencing, SUMO-conjugation pathways, or epigenetic regulation will find the polyclonal format valuable for capturing multiple epitopes of the target, suitable for both standard chromatin extraction protocols and co-immunoprecipitation mass spectrometry approaches.