Anti-CBX3 (5G10) Antibody

Recognizing Chromobox protein homolog 3 (HP1γ), the Antibodies.com mouse monoclonal antibody Anti-CBX3 (5G10) is a chromodomain-containing reader of histone H3 trimethylated at lysine 9 (H3K9me3) that supports heterochromatin maintenance, transcriptional silencing, and DNA damage response. Supplied as 100 µL of purified immunoglobulin in a Tris-Glycine buffer (0.1 M, pH 7.4) containing 150 mM NaCl, 0.2% sodium azide, and 50% glycerol, the unconjugated reagent is ready for direct labeling or secondary detection.

The clone has been validated for western blot, immunocytochemistry, immunohistochemistry, and immunoprecipitation across human, mouse, rat, and monkey samples, providing a cross-species tool for endogenous CBX3 detection. Researchers apply 5G10 to map HP1 isoform distribution, characterize heterochromatin-associated complexes, and probe nuclear architecture in cell culture and tissue sections. Store refrigerated; protect from light and avoid repeated freeze-thaw cycles to preserve binding activity across multiple experiments.